| NVO | Novo Nordisk A/S | NYSE | Healthcare | $122.75 | -0.45% | -1.05% | 0.31% | $548,041,925,000.00 |
| VRTX | Vertex Pharmaceuticals Incorporated | NASDAQ | Healthcare | $393.48 | -0.18% | -0.37% | -0.57% | $101,399,796,000.00 |
| MRNA | Moderna, Inc. | NASDAQ | Healthcare | $102.00 | -0.52% | 5.38% | 1.78% | $38,862,000,000.00 |
| BNTX | BioNTech SE | NASDAQ | Healthcare | $86.17 | 0.58% | 1.20% | 0.32% | $20,484,826,584.00 |
| BGNE | BeiGene, Ltd. | NASDAQ | Healthcare | $132.08 | 0.52% | 0.21% | -1.09% | $13,746,531,368.00 |
| GMAB | Genmab A/S | NASDAQ | Healthcare | $28.32 | -0.49% | 0.84% | -0.21% | $1,865,835,224.00 |
| ARGX | argenx SE | NASDAQ | Healthcare | $358.82 | -0.97% | -0.43% | 0.33% | $20,911,651,762.00 |
| CRSP | CRISPR Therapeutics AG | NASDAQ | Healthcare | $56.16 | 0.54% | 1.86% | -0.92% | $4,475,297,005.00 |
| ARWR | Arrowhead Pharmaceuticals, Inc. | NASDAQ | Healthcare | $22.58 | 0.71% | 1.55% | 1.72% | $2,425,430,700.00 |
| GLPG | Galapagos NV | NASDAQ | Healthcare | $28.91 | -0.28% | -0.66% | -0.46% | $1,905,084,322.00 |
| GLPG.AS | Galapagos NV | AMS | Healthcare | EUR27.30 | 0.15% | 0.00% | -0.38% | EUR1,798,990,038.00 |
| BCRX | BioCryst Pharmaceuticals, Inc. | NASDAQ | Healthcare | $4.50 | -2.17% | 4.12% | -4.40% | $906,340,500.00 |
| MRUS | Merus N.V. | NASDAQ | Healthcare | $40.47 | -1.44% | -2.75% | -2.56% | $2,340,213,323.00 |
| PHVS | Pharvaris N.V. | NASDAQ | Healthcare | $18.42 | -13.07% | 1.71% | 5.86% | $963,185,705.00 |
| GERN | Geron Corporation | NASDAQ | Healthcare | $3.73 | 0.54% | 3.00% | 0.00% | $2,219,266,086.00 |
| SAVA | Cassava Sciences, Inc. | NASDAQ | Healthcare | $21.19 | -0.19% | 5.83% | -7.29% | $893,963,720.00 |
| NVAX | Novavax, Inc. | NASDAQ | Healthcare | $3.90 | 0.26% | 0.00% | -0.71% | $482,348,100.00 |
| NWBO | Northwest Biotherapeutics, Inc. | PNK | Healthcare | $0.51 | 1.11% | -2.00% | -0.59% | $581,349,867.00 |
| PHARM.AS | Pharming Group N.V. | AMS | Healthcare | EUR0.88 | -8.36% | 0.15% | -2.91% | EUR575,289,284.00 |
| AVXL | Anavex Life Sciences Corp. | NASDAQ | Healthcare | $3.81 | -5.93% | -0.23% | -1.18% | $312,716,475.00 |
| NKTR | Nektar Therapeutics | NASDAQ | Healthcare | $1.30 | -1.52% | -3.85% | 3.40% | $248,352,000.00 |
| INO | Inovio Pharmaceuticals, Inc. | NASDAQ | Healthcare | $10.20 | -7.27% | 3.38% | 0.30% | $232,490,293.00 |
| QURE | uniQure N.V. | NASDAQ | Healthcare | $4.72 | 1.29% | -0.57% | 2.98% | $225,775,677.00 |
| AGEN | Agenus Inc. | NASDAQ | Healthcare | $4.97 | -7.28% | 6.34% | 4.48% | $1,960,035,002.00 |
| OCGN | Ocugen, Inc. | NASDAQ | Healthcare | $1.32 | -10.81% | -8.56% | 2.76% | $338,570,175.00 |
| IMMP | Immutep Limited | NASDAQ | Healthcare | $2.21 | -1.78% | -4.98% | 5.41% | $2,620,910,732.00 |
| GNFT | Genfit S.A. | NASDAQ | Healthcare | $3.59 | 3.76% | -0.83% | -4.07% | $178,408,575.00 |
| PRQR | ProQR Therapeutics N.V. | NASDAQ | Healthcare | $1.86 | -4.12% | 11.16% | 0.53% | $145,937,088.00 |
| VXRT | Vaxart, Inc. | NASDAQ | Healthcare | $0.84 | -2.79% | -5.45% | 0.00% | $128,286,568.00 |
| CDXC | ChromaDex Corporation | NASDAQ | Healthcare | $3.79 | -5.01% | -7.23% | 0.58% | $284,177,990.00 |
| ATOS | Atossa Therapeutics, Inc. | NASDAQ | Healthcare | $1.42 | 8.40% | 4.55% | 10.58% | $177,931,770.00 |
| ORTX | Orchard Therapeutics plc | NASDAQ | Healthcare | $16.70 | 0.00% | 0.00% | 0.24% | $381,408,895.00 |
| AFMD | Affimed N.V. | NASDAQ | Healthcare | $5.10 | -3.59% | -3.48% | -2.90% | $76,193,571.00 |
| TNXP | Tonix Pharmaceuticals Holding Corp. | NASDAQ | Healthcare | $0.15 | -3.13% | 1.36% | -1.53% | $4,919,121.97 |
| NOVN | Novan, Inc. | NASDAQ | Healthcare | $0.06 | 0.54% | -1.48% | -19.54% | $1,462,495.22 |
| EDSA | Edesa Biotech, Inc. | NASDAQ | Healthcare | $4.36 | -1.80% | -7.35% | -4.00% | $13,638,184.00 |
| NRBO | NeuroBo Pharmaceuticals, Inc. | NASDAQ | Healthcare | $3.44 | -4.18% | -10.18% | -10.24% | $17,474,467.00 |
| CYAD | Celyad Oncology SA | NASDAQ | Healthcare | $0.47 | -9.62% | 0.07% | 0.00% | $10,619,159.00 |
| JAGX | Jaguar Health, Inc. | NASDAQ | Healthcare | $0.18 | 22.75% | 12.08% | -17.57% | $12,946,356.00 |
| AVTX | Avalo Therapeutics, Inc. | NASDAQ | Healthcare | $12.01 | -11.82% | 1.19% | 15.14% | $9,628,969.46 |
| IBIO | iBio, Inc. | AMEX | Healthcare | $1.77 | -5.35% | -6.06% | -2.44% | $3,285,120.00 |
| XCUR | Exicure, Inc. | NASDAQ | Healthcare | $0.58 | -3.53% | 6.19% | -5.57% | $4,880,669.65 |
| FRTX | Fresh Tracks Therapeutics, Inc. | NASDAQ | Healthcare | $0.91 | 0.00% | 0.00% | 1.06% | $5,321,507.40 |
| ZEAL | Zealand Pharma A/S | NASDAQ | Healthcare | $0.00 | 0.00% | 0.00% | 0.00% | $0.00 |
