| NVO | Novo Nordisk A/S | NYSE | Healthcare | $105.06 | 1.11% | 0.03% | 0.10% | $467,910,576,717.00 |
| VRTX | Vertex Pharmaceuticals Incorporated | NASDAQ | Healthcare | $450.97 | -0.73% | 0.67% | 0.66% | $116,350,260,000.00 |
| MRNA | Moderna, Inc. | NASDAQ | Healthcare | $41.11 | 6.95% | -2.57% | 2.79% | $15,827,350,000.00 |
| BNTX | BioNTech SE | NASDAQ | Healthcare | $113.13 | 4.88% | 5.38% | 1.97% | $27,121,758,143.00 |
| BGNE | BeiGene, Ltd. | NASDAQ | Healthcare | $190.51 | -0.23% | -1.01% | 0.76% | $20,177,887,214.00 |
| GMAB | Genmab A/S | NASDAQ | Healthcare | $20.65 | 0.19% | -1.28% | -0.04% | $1,346,683,857.00 |
| ARGX | argenx SE | NASDAQ | Healthcare | $605.92 | 0.55% | 1.26% | 2.67% | $36,408,216,788.00 |
| CRSP | CRISPR Therapeutics AG | NASDAQ | Healthcare | $47.88 | 3.26% | -2.18% | 3.47% | $4,081,048,256.00 |
| ARWR | Arrowhead Pharmaceuticals, Inc. | NASDAQ | Healthcare | $18.54 | 1.31% | -0.32% | 4.54% | $2,302,649,460.00 |
| GLPG | Galapagos NV | NASDAQ | Healthcare | $27.13 | 4.35% | 0.44% | 2.90% | $3,448,582,418.00 |
| GLPG.AS | Galapagos NV | AMS | Healthcare | EUR25.38 | 5.75% | 0.23% | 0.53% | EUR1,672,467,661.00 |
| BCRX | BioCryst Pharmaceuticals, Inc. | NASDAQ | Healthcare | $7.60 | 1.88% | -3.54% | 4.94% | $1,572,478,000.00 |
| MRUS | Merus N.V. | NASDAQ | Healthcare | $45.49 | 1.70% | -1.43% | 1.27% | $3,104,879,918.00 |
| PHVS | Pharvaris N.V. | NASDAQ | Healthcare | $22.29 | 5.94% | 0.20% | 11.78% | $1,202,300,310.00 |
| GERN | Geron Corporation | NASDAQ | Healthcare | $4.07 | 2.26% | -2.52% | 0.93% | $2,694,983,800.00 |
| SAVA | Cassava Sciences, Inc. | NASDAQ | Healthcare | $26.48 | -15.56% | -4.29% | 2.75% | $1,270,404,480.00 |
| NVAX | Novavax, Inc. | NASDAQ | Healthcare | $8.47 | 5.09% | -7.94% | -1.49% | $1,355,615,030.00 |
| NWBO | Northwest Biotherapeutics, Inc. | PNK | Healthcare | $0.27 | -4.74% | -6.94% | 0.64% | $341,691,438.00 |
| PHARM.AS | Pharming Group N.V. | AMS | Healthcare | EUR0.72 | 2.43% | -0.76% | -6.36% | EUR485,701,678.00 |
| AVXL | Anavex Life Sciences Corp. | NASDAQ | Healthcare | $9.11 | 1.00% | -2.84% | 5.28% | $770,116,838.00 |
| NKTR | Nektar Therapeutics | NASDAQ | Healthcare | $1.05 | 1.94% | -3.76% | 6.25% | $219,711,450.00 |
| INO | Inovio Pharmaceuticals, Inc. | NASDAQ | Healthcare | $4.07 | -0.25% | -4.81% | 6.68% | $114,813,227.00 |
| QURE | uniQure N.V. | NASDAQ | Healthcare | $5.78 | -1.37% | 1.04% | 4.82% | $281,593,120.00 |
| AGEN | Agenus Inc. | NASDAQ | Healthcare | $3.34 | 19.71% | -3.81% | 6.34% | $71,977,000.00 |
| OCGN | Ocugen, Inc. | NASDAQ | Healthcare | $0.91 | -0.50% | -5.14% | 2.60% | $263,384,421.00 |
| IMMP | Immutep Limited | NASDAQ | Healthcare | $1.93 | 0.52% | -4.59% | -0.96% | $2,342,824,404.00 |
| GNFT | Genfit S.A. | NASDAQ | Healthcare | $4.20 | -3.00% | 1.36% | 8.02% | $240,200,377.00 |
| PRQR | ProQR Therapeutics N.V. | NASDAQ | Healthcare | $3.62 | 0.56% | -0.75% | -0.54% | $295,629,345.00 |
| VXRT | Vaxart, Inc. | NASDAQ | Healthcare | $0.60 | -1.32% | 0.04% | -0.49% | $136,471,729.00 |
| CDXC | ChromaDex Corporation | NASDAQ | Healthcare | $7.44 | -0.80% | -4.63% | 3.20% | $565,231,680.00 |
| ATOS | Atossa Therapeutics, Inc. | NASDAQ | Healthcare | $1.22 | 1.67% | -8.67% | 5.11% | $153,442,650.00 |
| ORTX | Orchard Therapeutics plc | NASDAQ | Healthcare | $16.70 | 0.00% | 0.00% | 0.24% | $381,408,895.00 |
| AFMD | Affimed N.V. | NASDAQ | Healthcare | $2.62 | -0.76% | -1.32% | 0.00% | $40,088,389.00 |
| TNXP | Tonix Pharmaceuticals Holding Corp. | NASDAQ | Healthcare | $0.19 | -2.71% | -7.04% | 3.94% | $11,803,233.00 |
| NOVN | Novan, Inc. | NASDAQ | Healthcare | $0.06 | 0.54% | 0.00% | 0.00% | $1,462,495.22 |
| EDSA | Edesa Biotech, Inc. | NASDAQ | Healthcare | $2.17 | 4.33% | -7.95% | -0.98% | $6,991,319.02 |
| NRBO | NeuroBo Pharmaceuticals, Inc. | NASDAQ | Healthcare | $2.37 | 0.42% | -2.29% | 6.22% | $24,207,386.00 |
| CYAD | Celyad Oncology SA | NASDAQ | Healthcare | $0.47 | -9.62% | 0.00% | 0.00% | $10,619,159.00 |
| JAGX | Jaguar Health, Inc. | NASDAQ | Healthcare | $1.04 | 5.42% | -12.60% | 0.00% | $9,744,941.44 |
| AVTX | Avalo Therapeutics, Inc. | NASDAQ | Healthcare | $10.13 | 5.52% | 6.69% | -5.73% | $56,183,583.00 |
| IBIO | iBio, Inc. | AMEX | Healthcare | $2.64 | 7.32% | -9.02% | 0.00% | $22,791,120.00 |
| XCUR | Exicure, Inc. | NASDAQ | Healthcare | $18.38 | 22.13% | -22.00% | 5.51% | $34,911,192.00 |
| FRTX | Fresh Tracks Therapeutics, Inc. | NASDAQ | Healthcare | $0.71 | 0.00% | -4.05% | 0.00% | $4,227,641.99 |
| ZEAL | Zealand Pharma A/S | NASDAQ | Healthcare | $0.00 | 0.00% | 0.00% | 0.00% | $0.00 |
